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Alpine Altitude Climate Treatment for Severe and Uncontrolled Asthma

A significant proportion of patients with asthma remains uncontrolled, despite well-designed guidelines, effective pharmacological treatment and the increasing availability of biologicals. Suboptimal asthma control has a major impact on disease burden, quality of life and healthcare costs. Alpine altitude climate treatment (AACT) results in a rapid decrease in inflammation, and immunomodulatory downregulation, which enables the regain of asthma control as the basis for further improvement during multidisciplinary pulmonary rehabilitation.

Asthma is a chronic inflammatory airway disease, characterized by variable recurring symptoms, reversible airflow obstruction and airway hyperresponsiveness. Asthma symptoms include wheezing, chest tightness, breathlessness, and coughing. While asthma has an estimated global prevalence of ~334 million people, patients with severe asthma represent only 3% to 5% of this population.1 Asthma severity is assessed retrospectively from the level of required treatment to control symptoms and exacerbations. Managing severe asthma is a major challenge due to the heterogeneity of the disease, characterized by different clinical phenotypes and biological endotypes, and influenced by various comorbidities and risk factors.2 Severe asthma results in significant emotional, financial, functional and medication-related burdens.3

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