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A Novel Checkpoint Inhibitor Regimen for Classic Hodgkin Lymphoma
Pembrolizumab plus combination chemotherapy provided a high complete response rate in patients with relapsed or refractory disease.
Second-Line CAR T-Cell Therapy for Relapsed/Refractory Large B-Cell Lymphoma
Lisocabtagene maraleucel improved clinical responses and outcomes as compared with high-dose chemotherapy and autologous stem cell transplantation.
Survivors of Childhood Cancer Die Earlier than the General Population, but Causes Are Similar
Excess mortality is associated with initial cancer treatments and later risk factors.
Fitusiran: A Potential Option for Patients with Hemophilia A or B, with or Without Inhibitors
This investigational siRNA-based therapy shows promise in reducing bleeding episodes in males with severe hemophilia A or B with or without inhibitors and without thrombophilia.
Treatment of Chronic Myelomonocytic Leukemia: Decitabine vs. Hydroxyurea
Responses were improved with decitabine therapy compared with hydroxyurea, but event-free survival and overall survival were similar.
Frequent PSA Screening for Prostate Cancer Likely Leads to Overdiagnosis
Men who were screened more frequently received more prostate cancer diagnoses but not earlier treatment.
Use and Outcomes of Screening Colonoscopy in People Older Than 75
Many screening colonoscopies are done in patients with limited life expectancy.
Another Look at Trends in Managing Low-Risk Prostate Cancer
Use of active surveillance and watchful waiting clearly has increased overall, but there is demographic variability.
Laparoscopy-Assisted vs. Open Gastrectomy in Advanced Gastric Cancer
At five years, survival outcomes for the two surgical approaches were similar.