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Treatment Holidays from Tyrosine Kinase Inhibitors in Advanced Renal Cell Carcinoma
Compared with standard treatment schedules, holding treatment until evidence of disease progression did not lead to a clinically meaningful reduction in overall survival.
PET-Adapted Treatment of Hodgkin Lymphoma
Patients with bulky stage I–II disease were safely spared radiation therapy if they were PET-negative following two cycles of induction chemotherapy.
Gynecologic Surgery and Breast Cancer Risk
Risk for breast cancer varied depending on type of surgery and hormone replacement therapy in a large study of women with sisters who had breast cancer.
Hydroxyurea Effective for Stroke Prevention in Children with Sickle Cell Disease in Tanzania
This finding is a call to action for worldwide access to this treatment.
Do Chemoimmunotherapy Clinical Trial Results Apply to Real World Patients with Extensive-Stage Small-Cell Lung Cancer?
They appear to; however, outcomes differ between patients who do and do not meet clinical trial eligibility criteria.
Transplant Outcomes in Acute Myeloid Leukemia
Durable remission and improved survival were demonstrated for patients who achieved very low-level measurable residual disease in peripheral blood prior to allogeneic transplantation.
New Insights into Therapy Selection for Metastatic Castration-Sensitive Prostate Cancer
The benefits of triplet versus doublet regimens varied depending on the combination of agents and on disease burden in this meta-analysis.
TACE Added to Lenvatinib Improves Overall Survival in Hepatocellular Carcinoma
Some adverse events were more frequent with the addition of TACE, but safety was similar with and without TACE overall.
Appendectomy and Hemicolectomy Equivalent in Appendiceal Neuroendocrine Tumors
Resection of lymph node metastases found at hemicolectomy also had no effect on survival.